儿童慢性炎性疾病所致生长迟缓及其治疗

Pathogenesis and managements of growth retardation in children with chronic inflammatory diseases

儿童常见的慢性炎症性疾病,如类风湿性疾病和炎性肠病多伴有生长迟缓、青春发育延迟和成年矮身材。近年明确了慢性炎症性疾病的发病机制主要与促炎性细胞因子有关,它们经对促生长素轴和软骨生长板多个层面的负性调控影响与该症的生长迟缓密切相关。文章就以上领域近年的相关进展以及对生长迟缓干预的措施进行了讨论。[临床儿科杂志,2007,25(12):961-964]

Growth retardation, delayed puberty and persistent short stature are commonly observed in children with chronic inflammatory diseases, such as rheumatoid diseases and inflammatory bowel diseases. The important role played by pre-inflammatory factors, such as TNF-α and IL-1β in the pathogenesis of chronic inflammatory diseases has gained more and more attention recently. Multiple negative regulatory effects of these factors on somatotropin-axis and growth plates may explain growth retardation observed in patients with chronic inflammatory diseases. This review will discuss recent advances in the pathogenesis studies and managements of growth retardation in these patients.