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内皮祖细胞的来源及应用 被引量：3

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摘要 内皮祖细胞（endothelial progenitor cells，EPC）是能自我更新、增殖分化为内皮细胞的多能干细胞，具有迟发性高增殖潜能及定向归巢特性。EPC细胞表面既存在造血干细胞表面标志，如CD34、CDl33，又存在内皮细胞表面标志VEG—FR-2，它可以摄取乙酰化低密度脂蛋白，具有yon Willebrand因子，在体外培养中具有特异的形态特征。它与血管新生、心血管组织工程内皮化等关系密切，在基础研究、肢体缺血性疾病及心血管疾病等领域有关EPC的研究非常活跃，从而为治疗缺血性疾病、血管组织工程及肿瘤治疗提供了新的思路和手段。
作者 李伟（综述） 杨丽娟（综述） 吴忠仕（审校）
机构地区 山东省滨州医学院附属医院胸心外科 滨州医学院生理教研室 中南大学湘雅二医院心胸外科
出处 《现代临床医学生物工程学杂志》 2007年第2期116-119,共4页 Journal of Modern Clinical Medical Bioengineering
关键词 内皮祖细胞 WILLEBRAND因子 肢体缺血性疾病 细胞表面标志 血管组织工程 低密度脂蛋白 肿瘤治疗 cells
分类号 R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献40

  • 1Nishikawa SI, Fraser S, Fujimoto T, et al. All B calls are progeny of endothelial cells: Anewpers pective. Immunol Rev, 2000, 175: 112-119.
  • 2Falon P, Arentson E, Kazarov A, et al. bFGF positively regulates hematopoitic development. Development, 2000, 127 : 1931-1941.
  • 3Ceradini DJ, Kulkarni AR, CaUaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med, 2004, 10:858-864.
  • 4Gareia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science, 2003, 300 : 1155-1159.
  • 5Camargo FD, Green R, Capetenaki Y, et al. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med, 2003, 9:1520-1527.
  • 6Urbich C, Heeschen C, Aicher A, et al. Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation ,2003,108:2511-2516.
  • 7Kinnaird T, Stabile E, Burnett MS, et al. Local delivery of marrowderived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation, 2004, 109 : 1543-1549.
  • 8Planat-Benard V, Silvestre JS, Cousin B, et al. Plasticity of human adipose lineage cells toward endothelial cells: physiological and therapeutic perspectives. Circulation, 2004, 109:656-663.
  • 9Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are muhipotent and support myocardial regeneration. Cell, 2003, 114:763-776.
  • 10Wurmser AE, Nakashima K, Summers RG, et al. Cell fusion independent differentiation of neural stem cells to the endothelial lineage. Nature, 2004, 430:350-356.

二级参考文献43

  • 1李尹雄 卢圣栋.核酸的分离与纯化.现代分子生物学实验技术（第一版）[M].北京:高等教育出版社,1993.147-149.
  • 2Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization[J]. Circ Res, 1999 (85): 221-228.
  • 3Rafii S, Meeus S, Dias S, et al. Contribution of marrow-derived progenitors to vascular and cardiac regeneration[J]. Semin Cell Dev Biol, 2002(13): 61-67.
  • 4Lyden D, Hattori K, Dias S, et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth[J]. Nat Med, 2001(7): 1194-1201.
  • 5Shi Q, Rafii S, Wu M H, et al. Evidence for circula-ting bone marrow-derived endothelial cells[J]. Blood, 1998(92): 362-367.
  • 6Takahashi T, Kalka C, Masuda H, et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization[J]. Nat Med, 1999(5): 434-438.
  • 7Moore M A, Hattori K, Heissig B, et al. Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF, and angiopoietin-1[J]. Ann N Y Acad Sci, 2001(938): 36-45.
  • 8Asahara T, Takahashi T, Masuda H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells[J]. EMBO J, 1999(18): 3964-3972.
  • 9Jiang W G, Hiscox S. Hepatocyte growth factor/scatter factor, a cytokine playing multiple and converse roles[J]. Histol Histopathol, 1997(12): 537-555.
  • 10Matsumoto K, Tajima H, Nakamura T. Hepatocyte growth factor is a potent stimulator of human melanocyte DNA synthesis and growth[J]. Biochem Biophys Res Commun, 1991(176): 45-51.

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现代临床医学生物工程学杂志
2007年 第2期

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