Wnt信号转导通路在肿瘤中的研究进展

Update of the Wnt signaling path in tumor

Wnt信号转导通路具有传递生长刺激信号的作用,与细胞的发育、分化密切相关。Wnt信号转导通路的异常激活,可引起细胞异常增殖及分化而导致肿瘤的发生。另外,其信号转导通路在人类不同肿瘤中的作用是相互交织的,了解该通路在肿瘤发生过程中的转导及调控,有助于为临床诊断提供依据,为早期干预治疗提供方法。

The Wnt signaling path has a function of delivering the growth incitement signal, and it is closely related with the growth and differentiation of ceils. The unusual activation of the Wnt signaling path may cause abnormal propagation and differentiation of ceils and consequently the development of tumor. Besides, this signaling path serves an interactive function in different human tumors. Understanding the contribution of this signaling and early intervention of tumor. path in tumor formation may afford a basis for the clinical diagnosis