骨形态发生蛋白-2促进骨缺损修复的研究进展

Advances in researches on bone morphogenetic protein-2 for bone repair

骨形态发生蛋白(BMP)是转化生长因子β(TGF-β)大家族中的一员,其在骨发生、诱导、修复和骨量保持方面发挥着重要而关键的作用。BMP表达水平的高低直接影响间充质骨祖细胞分化和骨量产生水平。其中BMP-2是研究最广泛、诱导成骨活性最强的BMP之一。现就BMP-2促进骨修复的研究进展作一综述。

The bone morphogenetic protein （BMP） , as a member of the transforming growth factor beta （TGF-β） family, plays a pivotal role in the formation, induction, maintenance and repair of the bone. The expression level of BMP has a direct influence on the differentiation of mesenchymal osteoprogenitors and the regulation of osteoblastic features. Among BMP,, BMP-2 is the most widely studied and has the strongest activity in inducing bone formation. This article reviews the current advances in researches on BMP-2 for bone repair.