ATP881的生物学特征及其在妊娠期肝内胆汁淤积症发病机制中的作用
摘要
妊娠期肝内胆汁淤积症(intrahepatic cholestasis of preg—nancy,ICP)是妊娠期特发的肝脏疾病,通常在妊娠中晚期出现,产后迅速消失。临床上主要表现为皮肤瘙痒和黄疸;生化上以胆汁淤积为特征。此病对胎儿危害较大,可引起胎儿窘迫、早产、死胎、死产,且明显增加围产儿发病率和死亡率,
出处
《重庆医学》
CAS
CSCD
2007年第24期2566-2568,共3页
Chongqing medicine
参考文献19
-
1Oude Elferink RP. Cholestasis[J]. Gut, 2003,52 (Suppl 2) : ii42.
-
2van Mil SW, Klomp LW, Bull LN, et al. FIC1 Disease:a spectrum of intrahepatic cholestatic disorders [J]. Semin Liver Dis,2001,21(4) :535.
-
3Paulusma CC, Groen A, Kunne C, et al. Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport[J]. Hepatology,2006,44(1) : 195.
-
4Pawlikowska L,Groen A,Eppens EF,et al. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion[J]. Hum Mol Genet,2004, 13(8) : 881.
-
5Mullenbach R, Bennett A, Tetlow N,et al. ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy[J] Gut,2005,54(6) :829.
-
6van Mil SW,van Ort MM,van den Berg IE,et al. Ficl is expressed at apical membranes of different epithelial cells in the digestive tract and is induced in the small intestine during postnatal development of mice [J]. Pediatr Res, 2004,56(6) :981.
-
7Demeilliers C,Jacquemin E, Barbu E, et al. Altered hepatobiliary gene expressions in PFIC1:ATP8B1 gene defect is associated with CFTR downregulation[J] Hepatology,2006,43: 1125.
-
8Bull LN, van Eijk M J, Pawlikowska L, et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis[J]. Nature Genet, 1998,18 : 219.
-
9陈正琼,成娅.妊娠期肝内胆汁淤积症病因及治疗研究进展[J].重庆医学,2003,32(2):228-230. 被引量:3
-
10Trauner M, Boyer JL. Cholestatic syndromes [J]. Curr Opin Gastroenterol, 2003,19 (3) : 216.
-
1何桂平.63例妊娠期肝内胆汁淤积症的护理[J].医学信息,2010,23(6):1682-1683.
-
2张宝星.血管内皮生长因子与妊高征[J].医学信息(医学与计算机应用),2001,14(12):894-896.
-
3夏夷,曹广慧.妊娠期肝内胆汁淤积症发病机制研究进展[J].基层医学论坛,2016,20(27):3846-3848. 被引量:4
-
4林玉平,马丽瑜,欧月英.15例妊娠期肝内胆汁淤积症的护理[J].福建医药杂志,2009,31(4):165-166.
-
5户瑞丽,杨君,骆亚平,石金河.妊娠期肝内胆汁瘀积症172例临床分析[J].中国误诊学杂志,2006,6(13):2527-2528.
-
6李敦华,王启玉,裘玉飞.妊娠期肝内胆汁淤积症与羊水粪染的关系及护理[J].浙江预防医学,2002,14(4):45-46.
-
7朱立新.早产的治疗进展[J].蛇志,2011,23(4):385-387.
-
8李桂清,颜芳,张乃羚.早产临床原因分析[J].中国初级卫生保健,2004,18(9):85-85. 被引量:4
-
9刘立杰.胎膜早破对分娩方式和妊娠结局的影响以及对胎儿危害的临床分析[J].中国医药指南,2012,10(35):155-156. 被引量:4
-
10杨秋.妊娠和药物[J].国外科技动态,1999,0(7):18-19.