男性肺癌患者血清性激素水平的分析

On Sex Hormones in Male Patients with Lung Cancer

目的探讨男性肺癌患者血清性激素水平的变化及临床意义。方法检测27例肺癌患者、19例肺良性病变患者和34例正常健康人员的血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)、孕酮(P)及催乳素(PRL),并进行统计学分析。结果肺癌患者血清T水平较正常对照组显著性降低(P<0.01),E2较正常对照组显著性增高(P<0.01),而P、LH、PRL及FSH较正常对照组无显著性差异(P>0.05);肺良性病变组血清T、P、E2、LH、PRL及FSH水平较正常对照组均无显著性差异(P>0.05)。结论男性肺癌患者体内存在性激素水平的失衡和紊乱,检测血清中T和E2的水平对肺癌的诊断和病情变化监测具有一定价值。

Objective To investigate the changes and clinical significance of serum sex hormones in male patients with lung cancer. Methods The follicle stimulating hormone （FSH）, luteinizing hormone （LH）, estradiol （E2）, testosterone （T）, progesterone （P） and prolactin （PRL） of 27 male patients with lung cancer proven clinically and pathologically, 19 male patients with benign pulmonary diseases and 34 healthy male subjects were examined and analyzed statistically. Results The serum levels of T were higher and those of E2 lower in male patients with lung cancer than those of healthy male subjects （P〈0. 01）, while the serum levels of P, LH, PRL and FSH showed no statistical difference between them （P〉0. 05）. The serum levels of T, P, E2, LH, PRL and FSH in male patients with benign pulmonary diseases were not significantly different to those in healthy male subjects （P〉0. 05）. Conclusion There are disorders and imbalances of sex hormones in male patients with lung cancer. The detection of T and E2 is valuable in diagnosis and treatment of lung cancer.