低分子肝素联合肠溶阿斯匹林治疗短暂性脑缺血发作疗效观察

The effects of combined Heparin LMW and Aspirin in the treatment of transient ischemic attack

目的观察低分子肝素联合肠溶阿斯匹林治疗短暂性脑缺血发作(TIA)的临床疗效和安全性。方法70例TIA患者随机分成观察组和对照组各35例,观察组应用低分子肝素和肠溶阿斯匹林,对照组单用肠溶阿斯匹林。14天时两组进行临床疗效评价。结果观察组的显效率为71.43%,总有效率为91.43%,高于对照组的45.72%、71.43%(P<0.01)。不良反应:两组在脑、消化道出血无差异。牙龈、皮肤黏膜出血两组有显著差异(P<0.05)。结论对TIA患者同时应用低分子肝素抗凝和肠溶阿斯匹林抗血小板聚集治疗有效且安全。

Objective To observe the clinical effects and security of combined Heparin LMW and Aspirin in treatment of transient isehemie attack. Methods 70 patients with TIA were randomly divided into two groups. In observation group （ n = 35 ）, which patients were treated with Heparin LMW and Aspirin. In control group （ n = 35 ）, which patients were only treated with Aspirin. The clinical effects were analyzed in both groups after 14 day. Results The effective rate was 71.43%, and the all effective rate was 91,43% in the observe group, which were higher than those in the control group （45, 72%, 71.43% ） （ P 〈0.01 ）. There was no significant difference between two groups in the intractable hemorrhage and the gastrointestinal hemorrhage in. And there were significant difference between the mueocutaneous hemorrhage and the gingival hemorrhage in two groups （ P 〈 0.05 ）. Conclusion Heparin LMW combined with Aspirin therapy is effective and safety in the treatment of patients with TIA.