p63、P504S、Ki67在乳腺良恶性疾病中的表达及意义

The Expression and Significance of p63,P504S and Ki67 in Breast Benign and Malignant Lesions

目的探讨p63、P504S、Ki67在乳腺良恶性疾病中的表达及临床意义。方法用免疫组化法研究54例乳腺良恶性疾病中p63、P504S及Ki67的表达。结果在乳腺良性病变组中p63阳性率是100%,P504S和Ki67均阴性;在浸润性导管癌及浸润性小叶癌中p63均呈阴性;在良恶性病变组之间,Ki67阳性表达率有显著性差异(P<0.01);导管癌P504S表达阳性,而小叶癌P504S则表达阴性。结论p63蛋白表达强度在良性肿瘤较强,恶性肿瘤最弱。P504S的染色有助于小叶癌与导管癌的鉴别诊断。Ki67的检测可作为鉴别乳腺良恶性疾病的一种辅助诊断方法。

Objective To study the expression and clinical significance of p63, P504S and Ki67 in breast benign and malignant lesions. Methods The expression of p63, P504S and Ki67 in 54 cases of the benign and malignant lesions examined by immunohistochemistry methods. Results The positive rate of p63 was expressed in benign breast lesions at 100% while P504s and Ki67 remained negative, appeared negative in invasive ductal carcinoma and invasive lobular carcinoma. Between benign breast lesions and carcinoma tissues, the positive of Ki67 had obvious distinctiveness（P〈0.01）. P504S of breast ductal carcinoma remained positive. P504S of breast lobular carcinoma lobular carcinoma of the breast was expressed as negative. Conclusion The expression strength p63 is higher in benign tumors and lowest in malignant tumors. P504S facilitates the clear identification .of lobular and duct carcinoma. Ki67 detection can be servea as an ancillary diagnosis method for identification of breast benign and malignant lesions.