244例造血干细胞移植的心血管并发症

Cardiovascular complications following stem cell transpIantation in 244 patients

目的:探讨造血干细胞移植(HSCT)治疗恶性血液病过程中心血管并发症的发生。方法:对1990年8月至2007年8月我院244例造血干细胞移植患者并发心血管疾病的情况进行回顾性分析。结果:244例无心血管病史和心电图正常的患者中有40例(16.39%)出现心血管系统井发症,除1例移植后早期心源性猝死外,其它移植患者的心血管症状均得到控制。心律失常19例(47.5%),是其中最多的心血管并发症,以窦性心动过速、频发性房性早搏、室性早搏、房室交界性早博为多;其次为心脏缺血性改变和高血压。结论:移植相关心血管并发症是影响造血干细胞移植效果的重要因素,应在移植全过程中予以监护和处理。

Objective： To investigate the incidence of cardiovascular complications following hematopoietic stem cell transplantation. Methods： A retrospective study was carried out for the clinical data from the patients undergone hematopoietic stem cell transplantation during the period of August 1999-August 2007 in the Union Hospital affililated to Fujian Medical University. Results： A total of 244 patients without any previous cardiovascular events undergone stem cell transplamation in out unit. Cardiovascular complications developed in 40 （16.39%） patients, and one case （0. 40%） died of cardiac sudden death at the early stage after transplantation. The others had recovered after the appropriate treatment., Among 40 patients, the major cardiovascular complication was arrhythmia （47.5%）, mainly shown as sinus tachycardia, atrial premature beat, ventricular premature beat and junctional premature beat. The following were myoeardiae ischemia and hypertension. Conclusion： Cardiovascular complication is one of the complications following stem cell transplantation that may have negative influence on success of transplantation, which should be taken into consideration during the whole process of transplantation.