比索洛尔对老年心绞痛的疗效及其对血浆C反应蛋白的影响

Effect of bisoprolol and its influence on concentration of C-reactive protein in aged patient with angina

目的:观察比索洛尔治疗老年稳定型心绞痛的临床疗效及对血浆C反应蛋白(CRP)的影响。方法:符合WHO诊断标准的50例老年稳定型心绞痛患者随机被分为比索洛尔治疗组(A组,30例,在常规治疗的基础上加用比索洛尔5mg/d),常规治疗对照组(B组,20例),疗程均为8周。另设健康对照组(C组,20例)。在治疗前、后测定CRP浓度,观察比索洛尔对心绞痛的疗效及对CRP的影响。结果:比索洛尔缓解心绞痛有效率达86.66%,心电图ST-T段改善率76.66%。血浆CRP水平治疗后显著下降(P<0.05)。结论:比索洛尔对老年稳定型心绞痛有较好疗效,同时可降低CRP浓度。

Objective： To study the effect of bisoprolol and its influence on concentration of C-reactive protein （CRP） in aged patient with angina. Methods： The 50 patients with stable angina were divided to bisoprolol group （30 cases, treated with bisoprolol 5 mg/d above the base of routine therapy）, and routine therapy group （20 cases）. Therapeutic course was 8 weeks all. The 20 normal persons were regard as control group. The concentration of CRP was detected before and after therapy. Results： The total effective power of angina in bisoprolol group was 86.66%, and its effective power of ECG was 76. 66% corresponded with that of routine therapy group. The level of CRP decreased significantly in bisoprolol group compared with routine therapy group （P〈0.05）. Conclusion： The bisoprolol not only decrease angina but also decrease the level of CRP.