丙硫苯咪唑瘤胃控释剂的含量测定及稳定性观察

Studies on Quantitative Method and Stability of an Intraruminal Controlled-release Device of Albendazole

用紫外分光光度法测定丙硫苯咪唑瘤胃控释剂的含量，方法简便，准确。其平均回收率为１００．０８％，ＣＶ为０．４％（ｎ＝６）。以经典恒温加速实验法进行了稳定性试验，结果表明，丙硫苯咪唑的热降解呈一级动力学过程，热化学反应的活化能为８３．１９ＫＪ／ｍｏｌ，２５℃降解的速度常数为６．４２３９×１０－５ｄ－１，半衰期为２９．５５年，预测出丙硫苯咪唑瘤胃控释剂的室温贮存有效期为４．５年，与室温留样观察结果一致。

Ultra violet spectrophotometry was used for determining the intraruminal controlled release device of albendazole (ICDA) , which was simple and accurate. The average recovery was 100.08%(CV=0.4%,n=6).Thermal stability of ICDA was determined by the classical isothermal method with accelerated test process. The results showed that the thermal mechanism of ICDA was first order reaction .Its activation energy, chemical rate constant (k 25 ) and half life(t 1/2 ) were 83.19KJ/mol,6.4239x10 5 d -1 and 29.55 years,respectively.The shelf life of ICDA might be 4.5 years, which was not different from the samples of ICDA determined by shelf observation method.