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猪链球菌2型引起脑膜炎致病机制的研究进展 被引量：8

Research Progress on the Pathogenic Mechanism of Meningitis Infected by Streptococcus Suis Serotype 2
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摘要 猪链球菌2型感染给世界养猪业造成巨大损失的同时也给公共卫生安全造成了威胁。至今对于猪链球菌2型的致病机制还不是很清楚,作者对国内外猪链球菌2型感染后引起机体脑膜炎的致病机制作一综述。 Streptococcus suis serotype 2 （SS2） caused world pig industry huge losses, and is also recognized as a zoonotic agent causing human disease. The pathogenesis of S suis infections is poorly understood. This review discusses the pathogenic mechanism of meningitis infected by SS2.
作者 沈艳 崔立 华修国
机构地区 上海交通大学农业与生物学院
出处 《中国畜牧兽医》 CAS 2007年第12期92-94,共3页 China Animal Husbandry & Veterinary Medicine
基金 上海市科技兴农重点攻关项目(05JC14018)"Ⅱ型猪链球菌病原体及预警系统的研究"资助
关键词 猪链球菌2型 脑膜炎 致病机制 streptococcus suis serotype 2 meningitis pathogenic mechanism
分类号 S852.611 [农业科学—基础兽医学]
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参考文献16

  • 1Benga L, Goethe R, Rohde M, et al. Non-encapsulated strains reveal novel inslghts in invasion and survival of Streptococcus suis in epithelial cells. Cell Microbiol, 2004(6) :867.
  • 2Busque P, Higgins R, Caya F, et al. Immunization of pigs against Streptococcus suis type 2 infection using a live avirulent strain. Can J Vet Res, 1997(61) :275.
  • 3Charland N, Nizet V, Rubens C E, et al. Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun, 2000(68) :637.
  • 4Esqleas M, Lacouture S, Gottschalk M. Streptococcus suis serotype 2 binding to extracellular matrix proteins. FEMS Microbiol Lett, 2005,244(1) :33-40.
  • 5Jobin M C, Gottschalk M, Grenier D. Upregulation of prostaglandin E2 and matrix metalloproteinase 9 production by human macrophage-like cells: synergistic effect of capsular material and cell wall from Streptococcus suis[J]. Microb Pathog, 2006(1) : 29.
  • 6Mariela S, Ghyslaine V, Dina Al-Numani, et al. Proinflammatory cytokine and chemokine modulation by Streptococcus suis in a whole blood culture system. Federation of European Microbiological Societies. Blackwell Publishing Ltd,2006(47):92.
  • 7Marcelo G, Mariela S. The pathogenesis of the meningitis caused by Streptococcus suis : the unresolved questions. Veterinary Microbiology, 2000(76) : 259-272.
  • 8Sanford S E. Gross and histopathological findings in unusual lesions caused by Streptococcus suis in pigs.Ⅱ. Central nervous system lesions. Can J Vet Res, 1987,51(4): 486-489.
  • 9Segura M, Stankova J, Gottschalk M. Heat-killed Streptococcus suis type 2 strains stimulate tumor necrosis factor alpha and interleukin-6 production by murine macrophages. Infect Immun, 1999,67(9) :46.
  • 10Segura M, Gottschalk M. Streptococcus suis Interactions with the Murine Macrophage Cell Line J774: Adhesion and Cytotoxicity. Infect Immun, 2002,70(8): 4312.

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中国畜牧兽医
2007年 第12期

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