红树林内源生真菌Sporothrix sp.#4335代谢产物的研究

Studies on the Secondary Metabolites of the Marine Mangrove Fungus Sporothrix sp.#4335

Diaporthin(1),松胞素4(2)是由一株红树林共生真菌Sporothrix sp.#4335中分离的两个化合物,其结构通过光谱分析确定。并首次对化合物1进行了抗人的肝癌细胞hepG 2及抑制人的DNA拓扑异构酶I(hTopoⅠ)的活性测试,结果显示,化合物1有一定的抗肿瘤活性(IC50为23μg/mL),及很强地抑制拓扑异构酶I的活性。

Diaporthin （1） and cytochalasa 4 （2） were identified by spectroscopic experiments, which isolated from a marine fungus Sporothrix sp. #4335 from the South China Sea. It was found that diaporthin （1） exhibited antitumor activity against hepG2 （ IC50 = 23 μg/mL） and strong inhibition of human DNA topoisomerase Ⅰ.