摘要
目的确定卵巢癌中8号染色体数目异常改变的频率,分析此改变与卵巢癌临床参数之间的相关性。方法应用着丝粒探针通过荧光原位杂交技术对40例卵巢癌标本进行8号染色体数目检测。结果40例卵巢癌患者中23例(57。5%)出现8号染色体数目增多,其中8号染色体数目变化与各临床参数之间存在相关性,但无统计学意义。结论8号染色体数目数目异常增多是卵巢癌特征性遗传改变,有可能成为卵巢癌分子诊断的标志物。
Objective To determine the frequency of chromosome 8 abnormal alteration in ovarian carcinoma, and analyze the association between the alteration and clinical parametre of ovarian carcinoma. Methods Fluorescence in situ hybridization (FISH) and DNA probes for centromere 8 were used to examine the copy number of chromosome 8 in ovarian carcinoma samples from 40 patiens. Results Tweenty three of 40 samples(57.5% ) had a gain in copy number of chromosome 8, and the alterations in chromosome 8 number were not statistically significantly associated with clinical parameter of these patients. Conclusion The gain of chromosome 8 is the characteristic genetic alteration in ovarian cancer tissue campared with normal tissue, and may be taken as the biomaker for tumor dignosis and progressional prediction in ovarian carcinoma..
出处
《国际遗传学杂志》
CAS
2007年第6期413-415,共3页
International Journal of Genetics
基金
国家自然科学基金(30370783)
关键词
荧光原位杂交
8号染色体
卵巢癌
Fluorescence in situ hybridization
Chromosome 8
Ovarian carcinoma