顺式铂氨化疗在非小细胞肺癌中作用的分子机制

Molecular Mechanisms of Cisplatin Chemotherapy in Non-Small Cell Lung Cancer

20多年来,非小细胞肺癌的最有效的化疗方法是以顺式铂氨(cisplatin)为基础的综合化疗。Cisplalin治疗非小细胞肺癌的进展,目前处于瓶颈阶段。此外,抗药性的产生也妨碍了化疗药物的作用。为了解在非小细胞肺癌中以cisplatin为基础化疗的分子机制,该文综述了cisplatin在非小细胞肺癌中参与细胞凋亡、细胞损伤修复等信号途径的最新研究进展,以阐明其作用模式和药物抗性的可能机制。

For more than two decades, the most effective systemic chemotherapy for non-small cell lung cancer （ NSCLC ） was cisplatin-based combination treatment. Unfortunately, the outcome of cisplatin therapy on NSCLC seems to have reached a plateau. For the understanding of the molecular basis of the cellular response to clsplatin-based chemotherapy in NSCLC, this review provides some insights into the signal pathways involved in the repair of cisplatin damage and the cell apoptosis or survival of NSCLC cells. With more and more molecular mechanisms of response to cisplatin-based therapy unraveled, this knowledge should provide a basis for further studies to improve the understanding of molecular events associated with NSCLC as well as to devise novel and effective therapeutic approaches to overcome the treatment plateau or reverse drug resistance in this disease.