摘要
西咪替丁（ＣＭＤ）４ｄ抑制法抗鼠疟作用结果显示：在剂量为５０ｍｇ／ｋｇ·ｄ、１００ｍｇ／ｋｇ·ｄ和２００ｍｇ／ｋｇ·ｄ时，该药对伯氏疟原虫氯喹敏感株、抗性株及约氏疟原虫氯喹敏感株感染小鼠的红内期疟原虫，均有明显的抑制作用，３组平均抑制率分别为６４．９５％、７７．９７％和５８．１６％。ＣＭＤ对伯氏疟原虫氯喹抗性株的抑制作用显著高于伯氏疟原虫氯喹敏感株（Ｐ＜０．０５）和约氏疟原虫氯喹敏感株（Ｐ＜０．０１）。
The anti-malaria effect of cimetidine(CMD) on infected mice was observed by using 4-day inhibition test. The results showed that CMD had significant inhibitory effect on the erythrocytic stage of plasmodium in mice infected with chloroquine-sensitive strain of P. berghei(P.b CQS), its resistant strain( P. b CQR) , and chloroquine-sensitive strain of P. yoelii(P.y CQS) when the doses of CMD were 50mg/kg·d, 100mg/kg·d and 200mg/kg·d.The average inhibition rates of the three plasmodium strains were 64. 95%, 77. 97% and 58. 16% respectively. The inhibition rate for P.b CQR group was significantly higher than that of P.b CQS( P <0.05) and P.y CQS( P <0.01) groups.
出处
《中国寄生虫病防治杂志》
CSCD
1997年第2期87-90,共4页
Chinese Journal of Parasitic Disease Control
基金
国家自然科学基金
关键词
西咪替丁
伯氏疟原虫
氯喹
约氏疟原虫
药理
Cimetidine\ Plasmodium berghei \ chloroquine\ Plasmodium yoelii
