靖江市高中毕业生乙型肝炎病毒感染状况

Infection Rate of HBV among High School Graduates in Jingjiang City of Jiangsu Province

目的调查江苏省靖江市2004—2007年高中毕业生乙型病毒性肝炎表面抗原(HBsAg)阳性及丙氨酸氨基转移酶(ALT)增高情况,了解该人群乙型肝炎病毒(HBV)感染状况。方法对靖江市20988名应届高中毕业生用酶联免疫吸附试验检测HBsAg,用速率法检测ALT。结果共检出HBsAg阳性1754人,总阳性率8.36%;男生阳性率(9.46%)高于女生(6.95%);农村学生阳性率(9.44%)高于城市学生(7.28%)。2004—2007年城市学生阳性率分别为9.31%,8.08%,6.74%,5.24%,呈逐年下降,2007年与前3年相比差别有统计学意义(P<0.05);农村学生阳性率分别为10.43%,9.36%,9.04%,8.64%,有所下降但差别无统计学意义(P>0.05);1754名HBsAg阳性学生中ALT升高者155名,占8.84%。结论江苏省靖江市2004—2007年高中毕业生HBsAg感染率较高,部分学生存在肝功能损害。应重视青少年乙型病毒性肝炎防治工作。

Objective To investigate the positive rates of HBsAg and abnormal rates of Alanine aminotransferase among high school graduates in Jingjiang city. Methods HBsAg were detected by ELISA and ALT was detected by rate assay among 20 988 high school graduates during 2004-2007 in Jingjiang city. Results The HBsAg positive students were 1754. The total positive rate of HBsAg was 8.36%. The positive rate of HBsAg of male （9.46%） was higher than that of female （6.95%）. The HBsAg positive rate of rural students （9.44%） was higher than that of urban students （7.28%）. HBsAg positive rates of urban students showed a decreasing trend during 2004-2007, the rates were 9.31%, 8.08%, 6.74% and 5.24%, respectively （P〈0.05）, but in suburban students didn＇t show such trend during these four years, the rates were 10.43%, 9.36%, 9.04% and 8.64%, respectively （P〉0.05）. There were 155 cases （8.4%） with increased ALT among 1754 HBsAg positive students. Conclusion The total positive rate of HBsAg among high school graduates in Jingjiang city from 2004-2007 was 8.36%. The HBsAg positive rate of male students was higher than that of female. The HBsAg positive rate of rural students was higher than that of urban students. 8.4% students were found ALT abnormal. We should intensify Hepatitis B vaccine in time to prevent the spreading of HBV.