依诺沙星片剂与胶囊剂体外溶出度比较

Comparison of the Dissolution Rate of Enoxacin Tablets and Capsules in Vitro

目的:测定5家不同厂家的依诺沙星片剂与胶囊剂的溶出度,考察产品质量。方法:按《中国药典》(2005版)采用紫外分光光度法,以9～1000 mL盐酸为溶出介质,转速100 r/min,温度(37±0.5)℃,测定依诺沙星片剂与胶囊剂体外溶出度。结果:5家不同厂家依诺沙星片利与胶囊利30 min内均溶出80%以上,符合《中国药典》(2005版)规定。溶出度参数m、T_d、T_(80)、K_r存在显著性差异(P<0.05)。结论:为保证临床用药安全有效,应严格按照《中国药典》规定控制该产品的内在质量。

Objective： To determine the in vitro dissolution rate of Enoxacin tablets and its capsules from 5 domestic plants. Methods： The dissolution rate was revealed according to Chinese Pharmacopoeia （2005） by UV spectrophotometry. Results： The results indicated that all the samples were dissoluted in 30 minutes. Very significant difference （P〈0.05） exists in the dissolution parameters in vitro ofTd ,T80 ,m and Kr of Enoxacin tablets and its capsules from 5 plants. Conclusion： It is necessary to control the dissolution rate of Enoxacin tablets and its capsules.