姜黄素对高脂血症大鼠血浆和肝脏超氧化物歧化酶和脂质过氧化物的影响

Effects of Curcumin on Plasma and Liver Superoxide Dismutase Activity and Lipid Peroxide Content in Hyperlipoidemic Rats

观察了姜黄素对高脂模型大鼠的降脂作用，同时还观察了其对血浆和肝脏组织超氧化物歧化酶（SOD）和脂质过氧化产物丙二醛（MDA）含量的影响。结果显示，口服姜黄素40mg／kg·d共10周，可使高脂模型大鼠血清胆固醇和甘油三酯的含量下降（P＜0．05），血浆及肝脏的MDA含量下降（P＜0．05）。姜黄素可使血浆和肝脏的SOD活性略有升高，但统计学意义不明显（P＞0．05）。结果提示，姜黄素对高脂模型大鼠具有降低血脂和抗脂质过氧化的双重作用。这一作用可在抗动脉粥样硬化中产生有利影响。

Effects of curcumin on serum cholesterol (CH)and triglyceride (TG )in hyperlipiodemic rats were studied,as well as on plasma and liver superoxide dismutase(SOD)activity and malonaldehyde (MDA)content of the rats, Curcumin was given orally 40 mg per kilo body weight daily for 10 weeks. Serum CH and TG were decreased after curcumin administration (P<0. 05 as compared with the control ). The contents of MDA in plasma and liver of hyperlipoidemic rats were significantly increased,but the increase was inhibited in curcumin group. The activities of SOD in plasma and liver were mildly increased after curcumin administration,but no statistic significance was found. The results indicated that curcumin has an inhibiting effect on lipid peroxidation in hyperlipoidemic rats.