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吲哚酸2,3-二氧化酶与妊娠相关疾病 被引量：1

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摘要 吲哚胺2,3-二氧化酶(indoleamine2,3-dioxygenase,IDO)是肝脏以外唯一可催化色氨酸(Trp)经犬尿氨酸途径代谢的限速酶,γ干扰素(IFN-γ)能激活IDO,导致Trp缺乏,可抑制免疫细胞尤其是T细胞增殖。IDO主要表达在抗原提呈细胞和胎盘滋养细胞,在诱发宿主免疫防御、诱导母胎免疫耐受和神经系统调节中均发挥重要的免疫调节作用。就IDO和自然流产、子痫前期、感染性妊娠并发症和产后抑郁症等妊娠相关疾病的关系进行综述。
作者 赵芳 陈铎
机构地区 河北医科大学第二医院妇产科
出处 《国外医学（妇产科学分册）》 2007年第6期373-376,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 吲哚胺2 3-二氧化酶 妊娠 流产 子痫前期
分类号 R714.2 [医药卫生—妇产科学]
  • 相关文献

参考文献20

  • 1Shirey KA, Jung JY, Maeder GS, et al. Upregulation of IFN-γ receptor expression by proinflamroatory eytokines Influences IDO activation in epithelial cells [J]. J Interferon Cytokine Res, 2006, 26(1 ): 53-62.
  • 2Mellor AL, Keskin DB, Johnson T, et al. Cells expressing indoleamine 2, 3-dioxygenase inhibit T cell responses[J]. J Immunol, 2002, 168 (8): 3771-3776.
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同被引文献13

  • 1叶婧,狄文,吴霞.吲哚胺2,3双加氧酶与肿瘤免疫逃逸[J].现代免疫学,2009,29(1):76-79. 被引量：1
  • 2李雪莲,归绥琪,王海燕.绒毛及合体滋养层细胞吲哚胺2,3-二氧化酶表达与流产的关系[J].生殖与避孕,2006,26(1):16-20. 被引量：1
  • 3UYTTENHOVE C,PILOTTE L,THEATE I,et al.Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase[J].Nature Medicine,2003,9(10):1269-1274.
  • 4WIRLEITNER B,NEURAUTER G,SCHROCKSNADEL K,et al.Interferon-gamma-induced conversion of tryptophan:immunologic and neuropsychiatric aspects[J].Current Medicinal Chemistry,2003,10(16):1581-1591.
  • 5LI Y,TREDREGET E E,GHAFFARI A,et al.Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute[J].J Invest Dermatol,2006,126(1):128-136.
  • 6FRIBERG M,JENNINGS R,ALSARRAJ M,et al.Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection[J].Intern J Cancer,2002,101(2):151-155.
  • 7SANTOSO D I,ROGERS P,WALLACE E M,et al.Localization of indoleamine 2,3-dioxygenase and 4-hydroxynonenal in normal and pre-eclamptic placentae[J].Placenta,2002,23(5):373-379.
  • 8NISHIZAWA H,HASEGAWA K,SUZUKI M,et al.Mouse model for allogeneic immune reaction against fetus recapitulates human preeclampsia[J].J Obstet Gynaecol Res,2008,34(1):1-6.
  • 9石春燕,孙丽洲,德伟.子痫前期患者胎盘组织氧化应激的研究[J].江苏医药,2008,34(8):861-861. 被引量：2
  • 10周晓彬,纪新强,徐莉.医用统计学软件PPMS 1.5的组成和应用特点[J].齐鲁医学杂志,2009,24(1):29-32. 被引量：297

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国外医学（妇产科学分册）
2007年 第6期

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