摘要
DNA甲基化是表观遗传学研究的重要内容之一,并与多种肿瘤的发生、发展密切相关。其中子宫内膜癌是女性生殖道常见的恶性肿瘤之一,DNA异常甲基化在其发生、发展过程中也起着重要作用,如使雌激素受体(ER)、孕激素受体(PR)表达沉默、增加基因组DNA的不稳定性、原癌基因激活和抑癌基因及肿瘤负相关基因失活等。了解DNA异常甲基化在子宫内膜癌发生机制中的作用将有助于患者早期预防、早期诊断和改善预后。
出处
《国外医学（妇产科学分册）》
2007年第6期421-424,共4页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
参考文献20
-
1Amant F, Moerman P, Neven P, et al. Endometrial cancer[J]. Lancet, 2005, 366 (9484): 491-505.
-
2Esteller M. DNA methylation and cancer therapy: new developments and expectations[J]. Curt Oncol, 2005, 17( 1 ): 55-60.
-
3Jin F, Dowdy SC, Xiong Y, et al. Up-regulation of DNA methyltransferase 3B expression in endometrial cancers [J ]. Gynecol Oncol, 2005, 96(2): 531-538.
-
4Xiong Y, Dowdy SC, Xue A, et al. Opposite alterations of DNA methyhransferase gene expression in endometrioid and serous endometrial cancers[J]. Gynecol Oncol, 2005, 96(3 ): 601-609.
-
5Shiozawa T, Itoh K, Horiuchi A, et al. Down-regulation of estrogen receptor by the methylation of the estrogen receptor gene in endometrial carcinoma[J]. Anticancer Res, 2002, 22( 1A): 139-143.
-
6Ghabreau L Roux JP, Niveleau A, et al. Correlation between the DNA global methylation status and progesterone receptor expression in normal endometrium, endometrioid adenocarcinoma and precursors[J]. Virchows Arch, 2004, 445(2): 129-134.
-
7Leu YW, Yan PS, Fan M, et al. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer [J]. Cancer Res, 2004, 64(22): 8184-8192.
-
8Abal M, Planaguma J, Gil-Moreno A, et al. Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors[J]. Histol Histopathol, 2006, 21(2): 197-204.
-
9Helmle KE, Otto CJ, Constantinescu G, et al. Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair[J]. Gynecol Cancer, 2005, 15(6): 1089- 1096.
-
10Xiong Y, Dowdy SC, Eberhardt NL, et al. hMLH1 promoter methylation and silencing in primary endometrial cancers are associated with specific alterations in MBDs occupancy and histone modifications[ J ]. Gynecol Oncol, 2006, 103 ( 1 ): 321-328.
同被引文献10
-
1Gielen SC, Hanekamp EE, Hanifi-Moghaddam P, Sijbers AM, van Cool A J, Burger CW, Blok LJ, Huikeshoven FJ. Growth regulation and transcriptional activities of estrogen and Progesterone in human endometrial cancer cells [J]. Int J Gyneeol Caneer, 2006, 16 (1): 110-120.
-
2Dai D, Albita rL, Nguyen T, Laidler LL, Singh M, Leslie KK. A therapeutic model for advanced endometrial cancer: systemic progestin in combination with local adenoviral-mediated progesterone receptor expression[J]. Mol Cancer Ther, 2005, 4 (1): 169-175.
-
3Miyamoto T, Watanabe J, Hata H, Jobo T, Kawaguchi M, Hattori M, Saito M, Kuramoto H. Significance of progesterone receptor-A and -B expressions in endometrial adenocarcinoma [J]. J Steroid Biochem Mol Biol, 2004, 92 (3) : 111-118.
-
4Sakaguchi H, Fujimoto J, Hong BL, Nakagawa Y, Tamaya T. Drastic decrease of progesterone receptor form B but not A mRNA reflects poor patient prognosis in endometrial cancers [J]. Gynecol Oncol, 2004, 93 (2): 394-349.
-
5Palii SS, Van Embttrgh BO, SankpalUT, et al. DNA methylation inhibitor 5'-Aza-2-deoxycytidine induces reversibleGenome-wide DNA damage that is distinctly ntluenced by DNA methyltransferases 1 and 3B[J]. Mol Cell Biol, 2008, 28: 752-771.
-
6Anatoliy A. Melnikov, Denise M. Scholtens, Elizabeth L. Wiley, Seema A. Khan, and Victor V. Array-Based Multiplex Analysis of DNA Methylation in Breast Cancer Tissues[J]. Levenson J Mol Diagn, 2008, 10 (1): 93-101.
-
7Sasaki M, Dharia A, Oh BR, et al. Progesterone receptor B gene inactivation and CpG hypermethylation in human uterine endometrial cancer[J]. Cancer Res, 2001, 61 (1): 97-102.
-
8Simon Hughes and J Louise Jones The use of Multiple Displacement Amplified DNA as a control for Methylation Specific PCR, Pyrosequencing, Bisulfite Sequencing and Methylation-Sensitive Restriction Enzyme PCR BMC Mol Biol. 2007, 8: 91.
-
9陈锐,于丽,廖秦平.子宫内膜癌中孕激素受体亚型表达及其甲基化状态的研究[J].现代妇产科进展,2008,17(7):501-505. 被引量：3
-
10石敏,尹香花.HAND2甲基化在子宫内膜癌中的研究现状[J].医学综述,2015,21(15):2744-2746. 被引量：1
-
1朱剑宇,王伟,荚卫东.DNA甲基化与肝细胞癌[J].国际外科学杂志,2013,40(12):841-844. 被引量：1
-
2杨晗春,刘竞.慢性粒细胞白血病DNA甲基化的研究进展[J].北方药学,2013,10(4):44-46. 被引量：2
-
3巩艳,杨云生,郭明洲.肝癌的表观遗传学特征及其临床意义[J].胃肠病学和肝病学杂志,2010,19(4):306-308.
-
4贾岩,郭明洲,杨云生.胃癌的表观遗传学研究[J].胃肠病学和肝病学杂志,2009,18(2):92-96. 被引量：2
-
5姚成才,林从尧.FHIT基因与消化系统肿瘤[J].四川肿瘤防治,2003,16(3):187-190.
-
6张艺,孙海涛,于汀,徐丹,杨秀娟.CD44V6在胃癌组织中的表达及意义[J].航空航天医药,2007,18(2):99-99.
-
7廖罗罡睿,曾斌.抑癌基因PTEN在人类肿瘤中的发生和发展研究进展[J].现代医药卫生,2013,29(4):558-560.
-
8陈飚,傅肖岩.食管癌相关基因改变及表达的研究进展[J].福建医药杂志,2013(2):160-161.
-
9陈建玲,姜波玲,崔蕾,雷小敏.p53系列基因表达与宫颈病变恶性程度相关性的研究进展[J].中国妇幼保健,2007,22(27):3900-3902.
-
10陈建玲,姜波玲,崔蕾,雷小敏.p53系列基因表达与宫颈病变恶性程度相关性的研究进展[J].实用医学进修杂志,2007,35(4):205-208.
