谷氨酰胺对肝硬化患者低蛋白血症的临床研究

A clinical study of glutamine therapy in lower albuminemia patients with liver cirrhosis

目的观察谷氨酰胺治疗肝硬化低蛋白血症的疗效。方法选择血清白蛋白低于35g/L肝硬化病人66例,无糖尿病、肿瘤,排除其他疾病引起的低蛋白血症。治疗方法为G ln制剂(丙氨酰一谷氨酰胺)20g,静脉注射,每日一次,10天为一疗程,观察血清前白蛋白、血清白蛋白、丙氨酸氨基转氨酶的变化。结果血清白蛋白由治疗前(25.3±3.4)g/L增加到治疗后的(32.4±3.1)g/L,无明显不良反应。结论谷氨酰胺可增加白蛋白的合成,改善营养状况。

Objective To study the effects of glutamine on treatment of liver cirrhosis with lower albuminemia. Methods Sixty - six patients with liver cirrhosis have been studied. The patients were given glutamine per day for 10 days. Results After being treated for 10 days, the level of albumin increased from （ 25.3± 3.4 ） g/L to （ 32. 4 ±3. 1 ） g/L. No side effects were reported. Conclusion Glutamine can increase the level of albumin of liver cirrhosis patients and improve the nutrition condition.