白藜芦醇甙对大鼠内毒素休克的影响

The effect of polydatin on endotoxic shock in rats

用经煮沸灭活及反复冻融的大肠杆菌O_(111)B_4混悬液8×10^(10)/ml,静注复制大鼠内毒素休克模型,观察比较给白藜芦醇甙予先处理后再形成的内毒素休克大鼠与休克对照组。结果表明:白藜芦醇甙改善了内毒素休克大鼠的血压下降和血中白细胞,血小板的减少;各时点脉压差的降低明显大于休克对照组,表明心血管功能的代偿能力有所改善。对用白藜芦醇甙后如白细胞和血小板的改变,血浆中溶酶体和肿瘤坏死因子的释放减少和血细胞比积不升高进行了讨论。

The effects of polydatin (PD) on endotoxic shock were studied in rat models. Endotoxic shock was induced by vein infusion of crued extracted E. coli by repeated, frozen and melt [(8XlO10/ml) 0.3 ml/100 g BW]. into the rats jugular vein. Results showed: (1) PD prolonged the survival time and improved the lethal hypotension. (2) Compared with shock control group at 4 h after E. coli infusion, PD group had a higher WBC count and platelet count and a lower hematocrit. (3) PD reduced the level of plasma tumour necrosis factor in endotoxic shock.