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皮下脂膜炎样T细胞淋巴瘤的EB病毒感染和P53蛋白表达的关系 被引量：4

The Significance of Epstein-Barr Virus Infection and Expression of P53 Protein in Subcutaneous Panniculitis-like T-cell Lymphoma
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摘要 目的探讨皮下脂膜炎样T细胞淋巴瘤(SPTL)中EB病毒(EBV)的潜伏感染情况及其与P53蛋白表达的关系。方法采用EBER1/2原位杂交检测20例SPTL组织中的EBV感染;用免疫组化LSAB法检测P53蛋白表达。结果20例SPTL中5例(25%)EBER1/2原位杂交阳性,6例(30%)的P53阳性。统计学分析,二者具有相关性(r= 0.533,P<0.05)。结论部分SPTL病例伴EBV潜伏感染,伴有EBV感染的SPTL患者可能预后较差。SPTL组织中P53蛋白表达可能与EBV的感染有关。 Objective To investigate the Epstein-Barr virus （EBV） latent infection and its correlation with expression of P53 protein in the subcutaneous panniculitis-like T-cell lymphoma （SPTL）. Methods Twenty cases of SPTL were analyzed, In situ hybridization for EBER1/2 and immunohistochemical staining for P53 were employed in this study, Results In the 20 cases of SPTL,the positive rate of EBER1/2 was 25% （5/20） and that of the P53 protein expression was 30% （6/20）, The two rates showed correlated statistically （ r = 0. 533, P 〈 0, 05 ）. Conclusion Some of SPTL are accompanied with EBV latent infection, which may signify a poor prognosis in these cases. The expression of P53 protein in SPTL may be related to the EBV infection,
作者 万川 王琳 徐晨 李俸媛 刘卫平 李甘地
机构地区 四川大学华西医院皮肤性病科 江西省皮肤病专科医院 四川大学华西医院病理科
出处 《中国皮肤性病学杂志》 CAS 北大核心 2007年第12期714-716,共3页 The Chinese Journal of Dermatovenereology
基金 2005年四川大学华西医院留学回国人员科研启动基金(编号136050122)
关键词 淋巴瘤 T细胞 皮肤肿瘤 脂膜炎 EPSTEIN-BARR病毒 P53 Lymphoma, T-cell Skin neoplasm Panniculitis Epstein-Barr virus P53
分类号 R739.5 [医药卫生—肿瘤]
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参考文献13

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二级参考文献2

共引文献52

同被引文献24

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引证文献4

二级引证文献8

中国皮肤性病学杂志
2007年 第12期

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