摘要
哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是PI3K/Akt通路的下游分子,可接受生长因子、营养、能量等多种信号,是细胞生长和增殖的关键调节分子。许多肿瘤中存在有编码mTOR信号通路相关蛋白的基因突变,这些蛋白的异常表达可引起mTOR通路的过度激活。目前,以mTOR为治疗靶点成为肿瘤治疗的研究新热点。本文就近年来有关mTOR通路及其抑制剂在抗肿瘤方面的研究进展作一综述。
Mammalian target of rapamycin (mTOR) is a key downstream molecule of PI3K/Akt pathway. It integrates input signals from growth factors, nutrients and energy to regulate cell growth and proliferation via different cellular processes. Gene mutations of mTOR pathway-related proteins are very common in many carcinomas, Abnormal expression of these related proteins can result in aberrant hyperactivity of mTOR pathway. Therefore, mTOR-targeted therapy has shown promising role in the management of various cancers, This article reviewed the current status of researches on mTOR and its inhibitors in antitumor therapy.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第12期1397-1403,共7页
Chinese Journal of Cancer
基金
广东省自然基金重点项目(No.05200178)~~