改良viscocanalostomy术中新型植入物的实验研究

Experimental studies of Reforming viscocanalostomy with new implantation materials imp-lanted in rabbit eyes

目的:探索新型植入物可吸收牛心包补片、不可吸收牛心包补片在改良viscocanalostomy(VCO)中应用的安全性及有效性;方法:将18只新西兰白兔随机分为A、B两个实验组和C对照组,每组6只。在A、B组白兔改良VCO的巩膜腔隙中分别植入不可吸收牛心包补片、可吸收牛心包补片,C组不植入任何植入物。观察术后不同时间巩膜腔隙存留情况及周围组织反应情况。结果:A、B组术后滤过泡形成及存留时间均优于对照组。手术区域周围组织反应轻微,可吸收牛心包补片组反应更为轻微。巩膜滤过空腔的保持与植入物有关,术后12周时A、B组眼巩膜腔隙仍维持较好,C组眼手术区域瘢痕形成明显。结论:植入物有助于改良VCO术后引流道的抗瘢痕化;两种植入物都是安全的,可吸收牛心包组反应更为轻微,远期抗瘢痕化效果可能更好。

Objective：To evaluate the effect of inhibiting scar formation and safety of reforming viscocanalostomy with absorbable and non-absorbable pericardial patch implantation. Methods： 18 New Zealand white rabbits were equally divided into three groups as experimental groups A, B and control group C. One piece of non-absorbable pericardial patch was implanted into each eye of group A while absorbable one into each eye of group B.Nothing was implanted in group C during reforming viscocanalostomy. Internal structures and lasting time of the scleral space are observed. Results：The formed filter blebs lasted longer in group A and B than group C. The pathology process showed that the spaces in sclera of group A and B were remained while scar formation was found in control group at the twelfth week. Conclusion：Implantation of absorbable and non-absorbable pericardial patches in reforming viscocanalostomy is safe and effective that can inhibit scar formation. Reaction caused by absorbable pericardial patches is lighter than that of non-absorbable ones. Absorbable pericardial patches may lead to better result in inhibiting scar formation.