期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

抗癌新靶点及其靶向药物的研究现状 被引量：2

Current Status of Novel Anti-tumor Targets and Their Targeting Drugs
下载PDF
导出
摘要 综述近年来抗癌新靶点及其靶向药物的研究进展,其中包括与细胞信号转导有关的蛋白酪氨酸激酶、蛋白激酶C、法尼基转移酶、丝裂原激活的蛋白激酶等靶点和基质金属蛋白酶、拓扑异构酶、微管、G-四螺旋、热休克蛋白90等靶点及其靶向抗癌药的发现与研究。 The recent advances on novel anti-tumor targets and their targeting drugs, including discovery and research of the targets related to cellular signaling, such as PTK, PKC, FFase and MAPK, and other targets, such as MMPs, Topo, Microtubule, G-quadruplex and HSP90, and the targeting anti-tumor drugs thereof, were reviewed.
作者 刘文虎 贺殿 胥桂贤
机构地区 兰州大学药学院药物化学研究所
出处 《药学进展》 CAS 2007年第12期535-542,共8页 Progress in Pharmaceutical Sciences
关键词 抗癌靶点 细胞信号转导 细胞增殖 细胞凋亡 靶向药物 Anti-tumor target Cellular signaling Cell proliferation Cell apoptosis Targeting drug
分类号 R730.5 [医药卫生—肿瘤] R979.1 [医药卫生—药品]
  • 相关文献

参考文献29

  • 1Cohen P. Protein kinases-the major drug targets of the twenty-first century[J]? Nat Rev Drug Discov, 2002, 1(4) : 309- 315.
  • 2Jarvis W D, Grant S. Protein kinase C targeting in antineoplastic treatment strategies[ J]. freest New Drugs, 1999, 17 (3): 227-240.
  • 3Shao R G Shimizu T, Pommier Y. 7-Hydroxystaurosprinecu (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53[J]. Exp Cell Res, 1997, 234(2) : 388-397.
  • 4Sebti S M, Hamilton A D. Farnesyltransferase and geranylgeranyltransferase inhibitors in cancer therapy: important mechanistic and bench to bedside issues[J]. Expert Opin Investig Drugs, 2000, 9(12): 2767-2782.
  • 5Kloog Y, Cox A D. RAS inhibitors: potential for cancer therapeutics[JJ. Mol Med Today, 2000, 6(10) : 398-402.
  • 6Maemura M, Iion Y, Koibuchi Y, et al. Mitogen activated protein kinase cascade in breast cancer[J]. Oncology, 1999, 57(Suppl 2) : 37-44.
  • 7Takahashi S, Keto Y, Fujita T, et al. FR167653, a p38 mitogen activated protein kinase inhabitor, prevents Helieobaeter pylori-induced gastritis in Mongolian gerbils [J].Pharmacol Exp Ther, 2001, 296(1): 48-56.
  • 8李乾斌,徐文方,张震.抗癌作用新靶点及其抑制剂的研究进展[J].中国药物化学杂志,2004,14(6):379-384. 被引量：3
  • 9Bissett D, O'Byme K, Von P, et al. Phase Ⅲ study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer[J]. J Clin Oncol, 2005, 23(4): 842-849.
  • 10Brown P D. Ongoing trials with matrix metalloproteinase inhibitors[J]. Expert Opin Investig Drugs, 2000, 9(9): 2167-2174.

二级参考文献34

  • 1Claesson-Welsh L,Welsh M,ITO N,et al.Angiostatin induces endothelial cell apoptosis and activation of focal adhesion kinase independently of the integrin-binding motif RGD[J].Proc Natl Acad Sci USA,1998,95(10):5579-5583.
  • 2Zetter BR.Angiogenesis and tumor metastasis[J].Annu Rev Med,1998,49(1):407-424.
  • 3Fabbro D,Manley PW.Su-6668,SUGEN[J].Curr Opin Investig Drugs,2001,2(8):1142-1148.
  • 4Klem J.Current studies with PTK787,an oral inhibitor of vascular endothelial growth factor in colorectal cancer[J].Clin Colorectal Cancer,2003,3(3):147-149.
  • 5Wedge SR,Ogilvie DJ,Dukes M,et al.ZD6474 inhibits vascular endothelial growth factor signaling,angiogenesis,and tumor growth following oral administration[J].Cancer Res,2002,62(16):4645-4655.
  • 6Ross JS,Gray GS.Targeted therapy for cancer:the HER-2/neu and Herceptin story[J].Clin Leadersh Manag Rev,2003,17(6):333-340.
  • 7Grillo-Lopez AJ.Rituximab(Rituxan/MabThera):the first decade(1993-2003)[J].Expert Rev Anticancer Ther,2003,3(6):767-779.
  • 8Herbst RS,Hong WK.IMC-C225,an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer[J].Semin Oncol,2002,29(5 Suppl 14):18-30.
  • 9Singh SB,Lingham RB.Current progress on farnesyl protein transferase inhibitors[J].Curr Opin Drug Discov Devel,2002,5(2):225-244.
  • 10Riemann D,Kehlen A,Langner J.CD13-not just a marker in leukemia typing[J].Immunol Today,1999,20(2):83-88.

共引文献4

同被引文献20

引证文献2

二级引证文献13

药学进展
2007年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部