哌拉西林联合他唑巴坦、舒巴坦(4:1)的体外抗菌活性比较

Antibacterial activities of compounds of piperacillin tazobactam and piperacillin sulbactam(4∶1)against ESBLs-producing bacteria in vitro

目的:观察哌拉西林/他唑巴坦、哌拉西林/舒巴坦(4∶1)对临床分离的产ESBLs菌株的体外抗菌作用,比较其抗菌活性。方法:采用标准平皿稀释法对临床分离的产ESBLs大肠埃希菌和肺炎克雷伯菌进行药物敏感测定。结果:哌拉西林/他唑巴坦、哌拉西林/舒巴坦复方制剂(4∶1)对多数产ESBLs菌具有很好的抗菌作用。结论:哌拉西林/他唑巴坦抗菌效果优于哌拉西林/舒巴坦。

Objective： To study the antibacterial activities of different formulations of piperacillin-sulbactam （4：l）and piperacillin alone against ESBLs-producing bacteria of clinical isolates in vitro. Methods： Bacterial susceptibility testing was performed on 35 ESBLs-producing bacteria of clinical isolates using agar dilution method.Compared antibacterial activities of different formula compounds of piperacillin tazobactam and piperacillin sulbactam. Results： Piperacillin-sulbactam and Piperacillin-tazobactam with 4：1 ratio were highly active against most ESBLs-producing bacteria. Conclusion： In this formula compounds, the antibacterial activities of Piperacillin-tazobactam is better than Piperacillin-sulbactam.