摘要
目的:观察哌拉西林/他唑巴坦、哌拉西林/舒巴坦(4∶1)对临床分离的产ESBLs菌株的体外抗菌作用,比较其抗菌活性。方法:采用标准平皿稀释法对临床分离的产ESBLs大肠埃希菌和肺炎克雷伯菌进行药物敏感测定。结果:哌拉西林/他唑巴坦、哌拉西林/舒巴坦复方制剂(4∶1)对多数产ESBLs菌具有很好的抗菌作用。结论:哌拉西林/他唑巴坦抗菌效果优于哌拉西林/舒巴坦。
Objective: To study the antibacterial activities of different formulations of piperacillin-sulbactam (4:l)and piperacillin alone against ESBLs-producing bacteria of clinical isolates in vitro. Methods: Bacterial susceptibility testing was performed on 35 ESBLs-producing bacteria of clinical isolates using agar dilution method.Compared antibacterial activities of different formula compounds of piperacillin tazobactam and piperacillin sulbactam. Results: Piperacillin-sulbactam and Piperacillin-tazobactam with 4:1 ratio were highly active against most ESBLs-producing bacteria. Conclusion: In this formula compounds, the antibacterial activities of Piperacillin-tazobactam is better than Piperacillin-sulbactam.
出处
《中国医药导报》
CAS
2007年第12X期195-196,共2页
China Medical Herald
基金
常州市卫生局2004年立项课题
关键词
哌拉西林
他唑巴坦
舒巴坦
体外抗菌活性
Piperacillin
Sulbactam
Tazobactam
In vitro antibacterial activity