3-氯-4-[1,1,2-三氟-2-(三氟甲氧基)乙氧基]苯胺的合成研究

Study on synthesis of 3-chloro-4-[1,1,2-trifluoro-2-(trifluoromethoxy)-ethoxy] aniline

以3,4-二氯硝基苯为原料,经过高压水解和还原反应,合成了2-氯-4-氨基苯酚,再与全氟甲基乙烯基醚加成,得3-氯-4-[1,1,2-三氟-2-(三氟甲氧基)乙氧基]苯胺,总收率为72.0%,产物结构经元素分析、IR和1H NMR表征。该工艺具有原料易得、收率高、质量好、对环境污染小等特点。

2-Chloro-4-aminophenol was synthesized from 3,4-dichloronitrobenzene by high pressure hydrolysis and reduction reaction, afterwards the addition reaction with pedluoro-vinyl-pedluoro-methyl ether was conducted to synthesize 3-chloro-4- [ 1,1,2-trifluoro-2- （trifluoromethoxy） -ethoxy ] aniline. The overall yield was 72. 0%, the product structure was characterized by elemental analyses, IR spectra and 1H NMR,it has characteristics of ready availability of reactant, high yield, good quality, little pollution to environment.