摘要
目的:考察复方利多卡因喷雾剂的稳定性。方法:通过加速试验、长期试验,以高效液相色谱法(HPLC)测定复方利多卡因喷雾剂中盐酸利多卡因、硝酸甘油、氯霉素的含量,以及观测溶液的外观性状、pH值,考察本制剂的稳定性。结果:复方利多卡因喷雾剂在加速试验、长期试验中含量变化范围小,均在限度范围内,外观性状及pH值无明显变化。结论:复方利多卡因喷雾剂在室温贮藏条件下稳定性好。
Objective:To study the stability of the compound Lidocaine hydrochloride spray. Methods: We used high performance liquid chromatography to detect the content of Lidocaine hydrochloride, nitrolar and chlormycetin in compound Lidocaine hydrochloride spray and observed its appearance and characteristics,pH value and stability through accelerated test and long test run. Results:The content of Lidocaine hydrochloride,nitrolar and chlormycetin in compound Lidocaine hydrochloride spray showed a small change range, and the appearance and characteristics of the spray showed no obvious change. Conclusion :The stability of the compound Lidocaine hydrochloride spray is satisfactory.
出处
《黑龙江医药科学》
2007年第6期31-32,共2页
Heilongjiang Medicine and Pharmacy
基金
江苏省盐城市2004年第二批医学科技发展计划项目(编号:YK2004254)
关键词
复方利多卡因喷雾剂
稳定性
compound Lidocaine hydrochloride spray
stability