致病性奈瑟菌属免疫球蛋白Al蛋白酶最新研究进展

Study Progress of IgA1 Protease of Pathogenicity Neisser

一直以来,免疫球蛋白A1蛋白酶因其对人类IgA1的特异性切割导致黏膜免疫受损而倍受关注。随着生物学和免疫学研究的不断发展,近年来致病性奈瑟菌属IgA1蛋白酶的研究也在不断地深入,尤其是IgA1蛋白酶切割性能与IgA1铰链区变异之间的关系、自身输出的模式以及诱导T细胞免疫等新概念,使得研究者对IgA1蛋白酶有了更进一步的认知。

ImmunoglobulinA 1 （IgA1） protease is constantly attracting mote attention for its specific cutting,which can result in damaged mucous immune. With the development of biology and immunology, studies about IgA1 protease of pathogenicity neisser is going further,especially studies about the relationship between its cutting function and mutation of hinge area of IgA1, mode of autologeus export, T cellular immunity induction and so on.which can maka scholars to have a further recognition of IgA1 protease.