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Expressions of Beta-Catenin,SUFU and VEGFR-2 Proteins in Medulloblastoma 被引量：1

Expressions of Beta-Catenin,SUFU and VEGFR-2 Proteins in Medulloblastoma
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摘要 Objective： to investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma. Methods： Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues. Results： the abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues, A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma. Conclusion： Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma. Objective： to investigate the expressions of beta-catenin, SUFU and VEGFR-2 proteins in medulloblastoma. Methods： Immunohistochemical staining with SP method was conducted to determine the expressions of beta-catenin, SUFU and VEGFR-2 in 33 cases of medulloblastoma and 10 normal cerebellar tissues. Results： the abnormal expression rates of beta-catenin and VEGFR-2 in medulloblastoma were significantly higher than that in normal tissue. While the positive expression of SUFU gene in medulloblastoma was significantly lower than that in 10 normal cerebellar tissues, A significant negative correlation was found between beta-catenin and SUFU proteins and a positive correlation between beta-catenin and VEGFR-2 was found in medulloblastoma. Conclusion： Beta-catenin, VEGFR-2 and SUFU have important effects on the pathogenesis and development of medulloblastoma.
作者 张雄 张红梅 李昱 米粲
机构地区 Department of Pathology
出处 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2007年第4期299-303,共5页 中国癌症研究（英文版）
关键词 Beta-cateuln VEGFR-2 SUFU MEDULLOBLASTOMA Beta-cateuln VEGFR-2 SUFU Medulloblastoma
分类号 R739.41 [医药卫生—肿瘤]
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参考文献12

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同被引文献31

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Chinese Journal of Cancer Research
2007年 第4期

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