^1H-MRS和CT在非酒精性脂肪肝诊疗中的应用研究

Application of Proton Magnetic Resonance Spectroscopy （^1H-MRS） and CT in the Diagnosis and Evaluation of Therapeutic Effects in Nonalcoholic Fatty Liver Disease （NAFLD）

目的:应用磁共振质子波谱成像(1H-MRS)技术和CT定量诊断非酒精性脂肪肝(NAFLD)及评价药物疗效。方法:依中华医学会NAFLD诊断标准入选NAFLD患者22例,并与20例健康组对照。两组均行肝脏1HMRS扫描和CT平扫,计算肝内脂质含量(IHCL)和CT肝/脾比值。NAFLD组患者服用肝脂消胶囊8周,检测治疗前后IHCL和CT肝/脾比值的变化。结果:NAFLD组IHCL较正常组明显升高,CT肝/脾比值较正常组明显下降。经治疗后IHCL明显下降,CT肝/脾比值明显升高。结论:肝脏1H-MRS扫描可对肝脏内脂质含量进行准确定量,优于CT平扫。

Objective：To investigate the application of proton magnetic resonance spectroscopy （^1H-MRS） and CT in the diagnosis and evaluation of therapeutic effects in nonalcoholic fatty liver disease （NAFLD）. Methods： 22 patients were selected according to the Chinese Medical Association＇s （CMA） standard of the NAFLD in comparison with 20 healthy persons （as control group）. The severity of hepatosteatosis was evaluated by ^1H-MRS scan and CT scan of liver. The intrahepatic content of lipid （IHCL） and CT value ratio （liver and spleen） were measured. Patients in NAFLD group were treated with Ganzhixiao Capsule for eight weeks. Then all the above parameters were tested after treatment. Results： In NAFLD group IHCL calculated by ^1H-MRS was increased and CT value ratio was decreased significantly compared with the control group. After eight weeks treatment IHCL was decreased significantly while CT value ratio was increased significantly in NAFLD group. Conclusion： The intrahepatic content of lipid can be measured precisely by ^1H-MRS, which shows that ^1H-MRS is better than CT in case a quantitative diagnosis is needed.