肥胖妇女的血脂、血浆LPO及红细胞LPO、SOD水平的研究

The Study of Serum Lipids,Plasma LPO,Erythrocyte LPO and SOD in Obese Women

目的:探讨肥胖病妇女体内的氧化应激状态及部分影响因素。方法:检测肥胖病妇女(肥胖病组,69例)的体质量指数(BMI)、腰围、腹围、臀围和腰臀比值(WHR),血浆过氧化脂质(P-LPO)、红细胞过氧化脂质(RBC-LPO)和红细胞超氧化物歧化酶(RBC-SOD),血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-c)、高密度脂蛋白-2-胆固醇(HDL2-c)、高密度脂蛋白-3-胆固醇(HDL3-c)、低密度脂蛋白胆固醇(LDL-c)和极低密度脂蛋白胆固醇(VLDL-c),并与对照组(30例)进行比较。结果:肥胖组RBC-SOD降低,RBC-LPO、P-LPO增高,TG、VLDL-c增高、HDL2-c、HDL-c降低;BMI、WHR与LPO正相关,与RBC-SOD负相关;BMI、WHR与HDL2-c负相关,与TG、VLDL-c正相关;RBC-LPO/RBC-SOD与TG、TC、LDL-c、VLDL-c正相关。结论:女性肥胖病患者体内氧化应激增强,清除自由基能力下降,过氧化脂质增加。氧化应激增强的程度由全身和腹腔内的脂肪量共同决定。肥胖病患者体内超氧化物歧化酶减少和过氧化脂质增加与其动脉粥样硬化性脂质谱的形成有关。

Objective： To study the oxidative stress and some influence factors in female obesity. Methods： Plasma lipid peroxide（P-LPO）, erythrocyte LPO （ RBC-LPO ）, erythrocyte superoxide dismutate（RBC-SOD） and serum cholesterol （TC）, triglycerides （TG）, HDL-c, HDL2-c, HDL3-c, LDL-c, VLDL-c were assessed in 69 female obesity and 30 normal subjects. The body mass index（ B MI）,waist and hip circumferences and waist/hip ratio （WHR） were obtained at the same time. Results： There were lower RBC-SOD and HDL-c in female obesity compared with those of control. The levels of RBC-LPO, P-LPO, TG and LDL were increased in female obesity compared with those of control. There were positive correlations among BMI, WHR and LPO, and among BMI, WHR, TG and VLDL-c. There were negative correlations among BMI, WHR and RBC-SOD, and among BMI, WHR and HDL2-c. There were positive correlations among RBC-LPO/RBC-SOD, TG,TC, LDL-c and LDL-c. Conclusion： There might be an enhanced level of lipid peroxidtion and decrease of antioxidation in female obesity. The free radical might play an important role in the pathogenesis of the lipid abnormal in obesity.