妊娠高血压综合征孕妇血清与胎盘绒毛膜促性腺激素的检测

Clinical significance of HCG in both maternal serum and placental tissue in normal term women and patients with pregnancy induced hypertension

观察正常妊娠及妊娠高血压综合征（简称妊高征）时，β绒毛膜促性腺激素（ＨＣＧβ）在母血中的浓度及与胎盘组织分泌的ＨＣＧ变化的关系。方法用放射免疫法测定了４３例妊高征孕妇及１５０名正常孕妇（均为孕晚期）血清ＨＣＧβ，并用免疫组织化学方法对其相应的胎盘组织中的ＨＣＧ进行了定位及半定量研究。结果在妊娠晚期，ＨＣＧ主要定位于合体细胞，中间滋养细胞可见少量。血清及胎盘绒毛中该激素含量及相关关系分析表明，母体血清与胎盘绒毛合体细胞ＨＣＧ含量呈显著正相关（Ｐ＜０．０１）。另外妊高征患者血清ＨＣＧβ及胎盘绒毛ＨＣＧ含量，均明显高于对照组（Ｐ＜０．０１）。结论妊娠晚期母血中ＨＣＧ主要由胎盘合体细胞产生。ＨＣＧ可能作为母体对胎儿、胎盘抗原的异常免疫反应的重要介质，在妊高征的发病中起一定作用。

Objective To determine the maternal serum level of HCGβ and the hormones in normal term women and patients with pregnancy induced hypertension. Method Semiquantitative immunohistochemistry of placental tissue was used in 193 normal term women and patients with pregnancy induced hypertension (PIH). results A strongly positive correlation between the maternal serum level of HCG and the immunostained positive syncytiotrophoblasts (ST) was found (correlated coefficient: 0.65, P <0.01). Maternal serum HCG was produced mainly from placental ST. Serum HCGβ and HCG positive cells of the placenta were obviously higher in patients with PIH than those in normal term women ( P <0.01). An increase of HCG level was noted in maternal serum and the placental tissue with PIH. Conclusion Abnormal higher HCG level may affect the pathogenesis of PIH.