急性冠脉综合征患者蛋白C活性测定及降纤酶对其的影响

The protein C activity in patients with acute coronary syndrome and effects of deifibrase on it

目的观察急性冠脉综合征病人生理性抗凝因子蛋白C活性情况,了解降纤酶对蛋白C活性的影响并探讨其作用机制。方法测定12例急性心肌梗死(AMI)、28例不稳定性心绞痛(UAP)病人及12例健康人蛋白C活性及纤维蛋白原(Fig)值,并观察降纤酶对UAP病人蛋白C活性及Fig的影响。结果AMI及UAP病人蛋白C活性及Fig明显高于健康人。应用降纤酶组,用药后Fig下降,蛋白C活性略升高,但对照组蛋白C活性于治疗1周后呈下降趋势。结论(1)急性冠脉综合征病人蛋白C活性及Fig值均升高。(2)降纤酶可有效降低Fig,并可使蛋白C活性略升高,因此其增强纤溶活性的作用可能与活化蛋白C有关。

Objective To observe the protein C activity in patients with acute coronary syndrome and to explore the effects of defibrase on protein C activity and their effective mechanism, Methods The plasma protein C activity and fibrinogen（Fig） levels were respectively measured in 12 patients with acute myocardial infarction（AMl） ,28 patients with unstable ang/na pectoris and 12healthy subjects. The effects of defibrese on protein C activity and Fig in patients with UAP were investigated. Results Group AMI and group UAP had significantly higher protein C activity and plasma Fig levels compared with healthy subjects. The plasma Fig levels declined ,and protein C activity slightly elevated in deft- brase-treated patients,while protein C ativity showed decuning tendency in control group. Conclusions （ 1 ） The protein C activity and plasma Fig levels both elevated in patients with acute coronary syndrome. （2）Defibrase could effectively decline Fig and slightly elevate the protein C activity. Therefore promoting the fibrinolysis activity of deilbrase is probably correlated with declining Fig and activating protein C.