高血压引起颈动脉狭窄成因分析

Causal Analysis of Carotid Artery Stenosis Resulting from Hypertension

高血压与颈动脉狭窄存在许多相关联系,颈动脉狭窄与动脉粥样硬化的发生机制一致。高血压在动脉粥样硬化的发生中起主导作用。血管内流体压力的突然升高,在血管分叉处产生涡流;液体在血管内流动对管壁产生不同的应力,一般分流体切应力、轴向应力和压应力3种,其中流体切应力最为重要。本文综述高血压引起颈动脉狭窄的发生机制,重点探讨血压对血管壁所造成的切应力引起的血管内皮细胞受损,通过影响血管内皮细胞的形态、结构和功能,并影响血管通透性,从而有助于脂质沉积的病理学机制。

Hypertension and carotid atery stenosis have many correlations. Carotid atery stenesis Hasthe same pathogenesis to artherosclerosis. Hypertension play a leading effect during the genesis of artherosclerosis. When the pressure of liquid in the tract rises abruptly,there will be a bow wave in tract crotch. The liquid can produce different stress to the wall of tract during floating. Generally, it can be divided into three types of floating stress, spindling stress and pressing stress, among which floating stress is the most important. The article reviews mechanism of action of caroid artery resulting from hypertension, especially debates vascular endothelial injury resulting from shear stress of vascular wall caused by hypertension, which can also affect vasopermeability by affecting the morphans, structure and function of vascular endothelium. These studies are helpful to the recognition of pathological mechanism of lipideses.