参麦注射液联合镁对心力衰竭患者血浆脑钠肽及心功能的影响

The Effect of Shenmai Injection Combined with Magnesium on Plasma Brain Natriuretic Peptide(BNP) Level,and Cardiac Function in Patient with Congestive Heart Failure(CHF)

目的观察参麦注射液联合镁对充血性心力衰竭(CHF)患者血浆脑钠肽及心功能的影响。方法选择慢性充血性心力衰竭患者60例,随机分对照组30例和治疗组30例。对照组应用常规抗心衰药物治疗,应用血管紧张素转换酶抑制剂、利尿剂、洋地黄制剂、β受体阻制剂。治疗组在常规抗心衰治疗基础上加用参麦注射液和氯化镁。每组疗程21 d。所有患者治疗前后测血清镁浓度和血浆脑钠肽浓度,行超声心动图评价心脏收缩功能的改善情况。结果经治疗后治疗组心衰疗效优于对照组,治疗组LVEF较治疗前明显增加,也明显高于对照组治疗后水平,血浆脑钠肽下降率大于常规抗心衰组,血清镁浓度高于对照组。结论在常规心衰治疗的基础上加用参麦注射液和氯化镁能有效改善充血性心力衰竭患者的心脏收缩功能,同时能显著降低血浆脑钠肽的含量。

Objective To observe the effects of Shenmai injection combined with magnesium on plasma brain natriuretic peptide （BNP） level,and cardiac function in patient with congestive heart failure （CHF）. Methods 60 patients with CHF were divided randomly into two groups, 30 patients in the control group,30 patients in the treatment group. The control group was treated with regular anti heart failure drug（ ACE inhibitor, digosin and diuretic, Betablock ）. The treatment group was treated with Shenmai injection and magnesium on the basis of above regular treatment. Each group was treated for 21days. The concentration measured of magnesium and BNP were measured before and after the treatment. In each group echocardiography was performed in all patients prior and after the treatment to evaluate the improvement of cardiac function. Results The test showed that the treatment effect of heart failure in treatment group was higher than control group, and the LVEF was significantly increased in treatment group （P 〈 0.05 ）, and the decrease rate of BNP in plasma was higher than CHF treatment group,the concentration magnesium in plasma was higher than control group（ P 〈0.05 ）. Conclusion Shenmai injection combined with magnesium can improve cardiac function and the value of BNP can be reduced obviously.