拉米夫定联合中药肝肾饮治疗乙型肝炎病毒相关性肾炎的研究

Therapy reaction of lamivudine with Chinese medcine Ganshen-Yin on hepatitis B virus-associated glomerulonephritis

目的:观察拉米夫定结合中药肝肾饮治疗临床表现为肾炎综合征的乙型肝炎病毒相关性肾炎(HBV-GN)的疗效。方法:18例符合条件的HBV-GN患者,随机分成治疗组和对照组,对照组口服拉米夫定100mg/d,治疗组在对照组基础上加用中药肝肾饮,治疗12个月,随访6个月。结果:两组患者治疗后24小时与治疗前比较尿蛋白定量、血清白蛋白及肾功能的差异有统计学意义,治疗组和对照组在治疗后24小时尿蛋白定量、肾功能比较,差异有统计学意义。两组中1例患者因使用拉米夫定出现YMDD变异,1例患者因使用拉米夫定出现头痛。结论:拉米夫定结合中药肝肾饮治疗乙型肝炎病毒相关性肾炎安全有效,且较单纯应用拉米夫定的对照组疗效为佳。

Objective： To explore therapy reaction of lamivudine with Chinese medcine Ganshen-yin on hepatitis B virusassociated glomerulonephritis （HBV-GN） patients. Methods： Ten-eight HBV-GN patients were randomly divided into 2 groups, control group was treated with lamivudine 100mg/d, the same managements and Chinese medcine Ganshen-yin for therapy group, all patients were treated for 12 months, follow up 6 months. Results： There were significant difference or extremely significant difference of 24h urine protein, serum albumin and renal function, between post-treatment and prior treatment of 2 groups. And, there was significant difference of 24h urine protein and renal function of post-treatment between 2 groups. There was 1 patient appeared YMDD variation, after using lamivudine for 9 months, 1 patient had a headack because of using lamivudine. Conclusion： The studies have provided the evidence that HBV-GN has beneficial response to lamivudine with Chinese medcine Ganshen-yin therapy.