肝癌患者手术前后T细胞亚群的变化特点及其意义

Characteristics and significances of blood subgroups of lymphocyte T before and after operation on the patients with liver cancer

目的:探讨肝癌患者手术前后外周血T淋巴细胞亚群的变化特点。方法:应用APAAP法测定30例肝癌患者手术前后的CD3、CD4和CD8细胞的阳性细胞百分率及其比值,并与正常对照组比较分析。结果:30例肝癌患者手术前CD3,CD4及CD4/CD8比值明显低于正常对照组,差异有显著性(P<0.01),手术后CD4/CD8的比值有明显提高,差异也有显著性(P<0.01),提示肝癌患者手术前后CD4/CD8比值有显著改变。结论:监测外周血CD4/CD8的比值可作为评价肝癌患者病情及手术后预后的一个参考指标。

Ahn：To study the proportion of blood subgroups of lymphocyte T before and after operation on the patients with liver cancer. Methods： The subgroups of lymphocyte T reagent APAAP from BeiJing Biotinge biotech company was used to detect the positive percentage of CD3, CD4 and CD8 T cell, and compare with the controlled group. Results： CD3, CD4 and CD4/CD8 reduced obviously before the operation （P 〈 0. 01 ）, while after the operation CD4/CD8 increased rapidly. These results showed that CD4/CD8 has notable changed before and after operation. Conclusion：The change of the proportion of blood subgroups of lymphocyte T of the patients with liver cancer can be used as an index of the state of illness, and prognosis.