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组蛋白乙酰化/去乙酰化与肺部疾病 被引量：2

Acetylation/Deacetylation of Histone and Lung Diseases
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摘要 组蛋白乙酰化修饰与基因的表达调控相关,参与了各种肺部疾病的病变过程。组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。二者之间的动态平衡在特定条件下被破坏,会导致基因转录的失调,引起基因表达的异常。 The acetylation of histone is related to gene expression and regulation,which takes part in the pathological courses of all kinds of lung diseases.The acetylation and deacetylation of histone is charged by a pair of protea se with antistatic function on each other,which are histone transacetylase and histone deacetylase.If the dynamic equilibrium between them was destro yed under certain condition,it will result in disturbance of genetic trans cription as well as abnomal gene expression at last.
作者 邹志 李万成
机构地区 泸州医学院附属医院呼吸内科
出处 《医学综述》 2007年第23期1763-1765,共3页 Medical Recapitulate
关键词 肺疾病 组蛋白 组蛋白乙酰基转移酶 组蛋白去乙酰化酶 基因表达 Lung diseases Histone Histone acetyltransferase Histone deacetylase Gene expression
分类号 R563 [医药卫生—呼吸系统]
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参考文献23

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二级参考文献2

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同被引文献19

  • 1李泽庚,彭波,张杰根,张念志,韩明向.肺气虚证模型大鼠的建立[J].北京中医,2005,24(1):53-55. 被引量：50
  • 2许淑云,徐永健,张珍祥.NF-κB在平滑肌细胞增殖信号转导中的调控作用[J].国外医学（呼吸系统分册）,2005,25(4):285-288. 被引量：2
  • 3宋颖芳,张耀亭,李焕章.核因子NF-κB对气道平滑肌细胞增殖的影响[J].西北国防医学杂志,2007,28(1):32-34. 被引量：4
  • 4Sun Y,Sun D,Li F,et al.Downregulation of Sirt1by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549lung cancer cells. Lung Cancer . 2007
  • 5Glozak MA,Senqupta N,Zhang X,et al.Acetylationnext term and deacetylation of previous termnon-histonenext term proteins. Gene . 2005
  • 6De Ruijter AJ,Van Gennip AH,Caron HN, et al.Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochemical Journal . 2003
  • 7Wegener,D,Hildmann,C,Schwienhorst,A.Recent progress in the development of assays suited for histone deacetylase inhibitor screening. Molecular Genetics and Metabolism . 2003
  • 8Miao,F. et al.In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. Journal of Biological Chemistry . 2004
  • 9ADCOCK I M,TSAPROUNI L,BHAVSAR P,et al.Epigenetic regulation of airway inflammation. Current Opinion in Immunology . 2007
  • 10Kouzarides,T.Chromatin modifications and their function. Cell . 2007

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二级引证文献13

医学综述
2007年 第23期

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