细胞因子在辅助生殖领域中的研究

Study of Cytokines in the Field of Assisting Reproducing

大量研究表明,通过测定血清、卵泡液或动物胚胎上的细胞因子,发现这些细胞因子对体外受精-胚胎移植的受精率、优质胚胎形成率、妊娠结局有着紧密联系,细胞因子在体外受精-胚胎移植妇女卵泡液中、血清中水平的增加;通过受体介导,以自身分泌、旁分泌及远距离作用形式对下丘脑垂体卵巢进行调控,并参与人体胚胎植入,妊娠维持及胎盘激素合成分泌过程的调节。随着体外受精胚胎移植技术的日新月异,卵巢内微循环调节卵泡发育的细胞因子的作用日益受到重视。

Many studies have shown that many cytokines have fu nd to have close re lationship with rate of fertilization of adosculation-embryo transplantation,rate of good embryogenesis,and pregnancy outcome by measuring its concent ration in serum,follicular and fluid on the animal embryo,which has increase d level in serum and follicular of women with adosculation-embryo transplant ation and can regulate hypothalamus-pituitary-ovarian by receptor in the f orm of self-secretion,paracrine and long-distance,which also takes part in the regulation of embryo implantation,maintenance of pregnancy and synthesi s and secretion of placental hormone.With the development of technique of ado sculation-embryo transplantation,cytokines regulating follicular development in ovary microenviroment are attracting more and more attention day by day.