强心冲剂对充血性心力哀竭家兔模型心钠素、血管紧张素Ⅱ的影响

Influence of Qiangxin Chongji on Atrial Natriuretic Polypeptide and Angiotensin Ⅱ of Rabbit Model with Congestive Heart Failure

目的:观察强心冲剂干预后充血性心力衰竭(CHF)家兔模型心钠素(ANP)、血管紧张素Ⅱ(AngⅡ)的变化,探讨强心冲剂对神经内分泌活性的影响。方法:将40只家兔随机分为4组,假手术组、模型组、地高辛组、强心冲剂组,每组10只。采用腹主动脉缩窄术建立家兔CHF模型,予强心冲剂和地高辛灌胃,检测并比较ANP、AngⅡ的活性。结果:CHF家兔模型ANP、AngⅡ活性显著升高,神经内分泌激素释放失衡,强心冲剂干预后,可以纠正其失衡状态,明显降低ANP、AngⅡ水平。结论:强心冲剂能显著纠正神经内分泌激素释放失衡状态,改善神经内分泌激素的激活,可以防止CHF的进一步恶化。

Objective：To probe the influence of Qiangxin Chongji （Infusion for strengthening the function of heart） on the activity of neuroendocrine of rabbit model with congestive heart failure （CHF） through observing the changes of atrial natriuretic polypeptide （ANP） and angiotensin Ⅱ （Ang Ⅱ）. Methods：The 40 rabbits were randomized into 4 groups with 10 in each： false operation group, model group, digoxin group, Qiangxin Chongji group. The CHF models were made by abdominal aorta constriction. The gastric perfusion with Qiangxin Chongji and digoxin was applied. The activity of ANP and Ang Ⅱ was tested and compared. Results：The activity of ANP and Ang Ⅱ was clearly strengthened and the neuroendocrine was imbalanced. Intervention of Qiangxin Chongji could correct this imbalanced condition, lowering ANP and Ang Ⅱ obviously. Conclusion：Qiangxin Chongji can remarkably correct the imbalanced hormone release of neuroendocrine and improve the hormone activation to prevent the CHF deterioration.