血液黏滞综合征与呼吸系疾病相关性的临床研究

Clinical Research on Blood Viscosity Syndrome and Respiratory Diseases

目的:探讨血液黏滞综合征(BVS)对急性气管—支气管炎、慢性阻塞性肺疾病、慢性肺源性心脏病的临床意义。方法:按年龄、性别和诊断分层随机法,分别纳入急性气管—支气管炎(A组)、慢性阻塞性肺疾病(B组)、慢性肺源性心脏病(C组)各40例,分别进行血液流变学检测后,用血液黏滞综合征血液流变学诊断软件进行诊断。结果:各组血液高黏滞综合征(BHS)和血瘀证的发生率分别为7.5%、72.5%、95.0%和5.0%、70.0%、97.5%,各组间比较有显著性差异(P<0.01),BHS的级别分别为(0.16+0.43)、(2.61+0.42)、(3.64+1.14),各组的比较有显著差异(P<0.01);C组的BHS和亚型的级别在治疗后均显著下降(P<0.01);在病情危重和有并发症时,BVS可表现为BHS级别快速增高或转变极重度的血液高—低黏滞综合征(BHLS)、血液低—高黏滞综合征(BLHS)或血液低黏滞综合征(BLS)。结论:BVS对急性气管—支气管炎、慢性阻塞性肺疾病和慢性肺源性心脏病的辅助诊断、疗效观察、判断预后和早期发现并发症有重要意义。

Objective：To probe the clinical significance of blood viscosity syndrome （BVS） for acute tracheal bronchitis, chronic obstructive lung disease and chronic cor pulmonale. Methods：With the stratified random sampling, the cases of acute tracheal bronchitis （group A）, chronic obstructive lung disease （group B） and chronic cor pulmonale （group C） were enrolled with 40 of each according to age, sex and diagnosis. After the blood rheology examination, the diagnosis was done with the BVS blood rheology diagnosis software. Results：The incidence of blood hi-viscosity syndrome and TCM blood stasis syndrome of all groups was 7.5%, 72.5% and 95%, 5.0%, 70.0% and 97.5% respectively, the difference was significant in comparison among all groups （P〈0.01）. The BHS degree was （0.16＋0.43）, （2.61＋0.42） and （3.64＋1.14） respectively, the difference was significant in the comparison among all groups （P〈0.01）. The BHS of group C and the degree of its subtype were obviously lowered after treatment （P〈0.01）. In the critical stage and when with complications, the BVS could be manifested as the BHS degree being quickly elevated, or changed to the extremely serious blood hi-low-viscosity syndrome （BHLS）, blood low-hi-viscosity syndrome （BLHS）, or blood low-viscosity syndrome （BLS）. Conclusion：BVS is significant for the accessory diagnosis, effect observation, prognosis and early discovery of acute tracheal bronchitis, chronic obstructive lung disease and cor pulmonale and their complications.