摘要
2-甲基-4-硝基-1H-咪唑经乙酸氯甲酯保护咪唑环上的1位N得1-乙酰氧甲基-2-甲基-4-硝基咪唑(3),继而和手性环丙硫酸酯反应,再经水解得R型-或S型-塞克硝唑,总收率均约38%(以3计)。
The stereoisomers of secnidazole were synthesized from 2-methyl-4-nitro-1H-imidazole by protection with chloromethyl acetate to give 1-acetoxymethyl-2-methyl-4-nitroimidazole （3）, which was reacted with chiral cyclic sulfate followed by hydrolysis with overall yields of about 38 % （based on compound 3）.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2007年第12期828-830,共3页
Chinese Journal of Pharmaceuticals
关键词
塞克硝唑
抗菌剂
立体异构体
合成
secnidazole
antimicrobial
stereoisomers
synthesis
