2,3,5-三-O-苄基-1-O-对硝基苯甲酰基-D-阿拉伯呋喃糖的合成

Synthesis of 2,3,5-tri-O-Benzyl-1-O-(p-nitrobenzoyl)-D-arabinofuranose

D-阿拉伯糖经甲基化、苄基化得1-O-甲基-2,3,5-三-O-苄基-D-阿拉伯呋喃糖,再经水解、由对硝基苯甲酰氯酰化制得核苷类药物中间体2,3,5-三-O-苄基-1-O-对硝基苯甲酰基-D-阿拉伯呋喃糖,总收率约45%。

2,3,5-tri-O-Benzyl-1-O-（p-nitrobenzoyl）-D-arabinofuranose was synthesized from D-arabinose by methylation and benzylation to give 1-O-methyl-2,3,5-tri-O-benzyl-D-arabinofuranose, which was subjected to hydrolysis and acylation with an overall yield of about 45 %.