中药芪龙风湿丸对类风湿关节炎患者外周血细胞因子IL-1,IL-6,TNF-α的影响

Effects of Qilongfengshiwan on cytokine IL-1,IL-6,TNF-α in peripheral blood of rheumatoid arthritis(RA) patients

目的采用中药为主的方法治疗类风湿性关节炎(RA),并进行患者外周血细胞因子(CK)的测定及观察治疗前后的变化。方法随机选择RA病人62例,其中治疗组42例以中药益气养阴,甘润辛通法为主自拟中药芪龙风湿丸治疗,同时予MTX每周5 mg,连服60天;对照组20例,予MTX每周5 mg,连续服用60天。同时观察药物对患者外周血细胞因子IL-1,IL-6,TNF-α的影响。结果两组外周血细胞因子治疗前均有异常表达,治疗后异常水平均有下降,中药组治疗前后自身比较,三种细胞因子的下调均有非常显著意义(P<0.01)。与对照组比较,治疗后中药组IL-1,TNF-α的下降有显著意义(P<0.05)。结论以益气养阴,甘润辛通法治疗RA,能改善外周血异常细胞因子表达,对RA病人临床症状和实验室指标均有一定改善作用。

Objective To investigate the effect of Qilongfengshiwan （a mixture of Chinese medicinal herbs） on cytokine IL-1, IL-6, TNF-α in peripheral blood of rheumatoid arthritis （RA） patients. Methods We selected 62 patients who were diagnosed RA the patients were randomly divided into two groups. One was treated with Qilongfengshiwan and MTX, the oth- er was treated with MTX only. Results Among the treatment group, the cytokine IL-I,IL- 6, TNF-α in peripheral blood of the patients was remarkably decreased compared to that of con- trol （P〈0.01）. Conclusion The therapeutic effects of Qilongfengshiwan on RA may par- tially related to down regulating cytokine of the peripheral blood.