葡萄柚中细胞色素P450酶抑制剂的研究进展

Research Development of CYP3A4 Inhibitors in Grapefruit

葡萄柚果汁中富含呋喃香豆素类化学成分,这些呋喃香豆素类化合物特别像6,7-DHB及其类似物能抑制药物代谢酶细胞色素P450,以致于提高特定药物口服生物利用率或阻碍致癌物质的活性。综述了近年来发现的呋喃香豆素化合物的类别、活性及合成方面的情况。

The grapefruit juice contains many furanocoumarins, especially 6＇ ,7＇-DHB and its analogues , which can inhibit the cytochrome P450 drug metabolizing enzyme （CYP3A4） and result in increasing the oral bioavailability of certain drugs or preventing the activation of carcinogens. In this article, the recent development of categories, activities, separation and synthesis of furanocoumarin were reviewed.