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怀牛膝对2型糖尿病大鼠脑组织p75基因表达的影响 被引量：6

Effect of Achyranthes bidentata Blume(BL) preparation on expression of P75 gene of cerebrum in type2 diabetic rats
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摘要 目的:研究怀牛膝(Achyranthes bidentata Blume,BL)水煎剂对2型糖尿病大鼠脑组织P75基因mRNA表达的影响。方法:随机选取以不同剂量怀牛膝水煎剂灌胃的2型糖尿病大鼠每组10只,以生理盐水灌胃的2型糖尿病大鼠及正常对照组大鼠各10只,用RT-PCR法测定脑组织P75基因mRNA的表达。结果:2型糖尿病大鼠脑组织P75基因mRNA的表达上调,服用怀牛膝水煎剂的2型糖尿病大鼠脑组织P75基因mRNA的表达下降。结论:怀牛膝水煎剂能降低2型糖尿病大鼠脑组织P75基因mRNA的表达。 Objection:To study the effect of Achyranthes bidentata Blume(BL) on the expression of the brain P75 gene mRNA in type 2 diabetic rats.Methods:Selecting 2 type diabetic rats with taken diverse dosage Achyranthes bidentata Blume(BL) and Physiological saline each ten rats in every group and natural ten rats in random,the expression of brain P75 mRNA was mensurated by RT-PCR.Results:the mRNA expression of Brain P75 in 2 type diabetic groups was higher than that of natural group(P<0.01),and that Achyranthes bidentata Blume(BL)groups were lower than that of type 2 diabetic model(P<0.01).Conclusion:Achyranthes bidentata Blume(BL) can decrease the mRNA expression of brain P75 in type 2 diabetic rats.
作者 董琦 郭新民 聂影 李宝龙
机构地区 牡丹江医学院 黑龙江中医药大学
出处 《中医药学报》 CAS 2007年第6期20-21,共2页 Acta Chinese Medicine and Pharmacology
关键词 怀牛膝 2型糖尿病 P75基因 MRNA Achyranthes bidentata Blume(BL) type 2 diabetic rats P75 Gene Gene expression
分类号 R285.5 [医药卫生—中药学]
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参考文献6

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共引文献19

同被引文献131

引证文献6

二级引证文献165

中医药学报
2007年 第6期

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