氢溴酸法合成1-溴代十二烷

Synthesis of 1-Bromododecane Using Hydrobromic Acid Method

以生产溴代金刚烷得到的副产品氢溴酸为原料,在浓硫酸存在的条件下与正十二醇进行反应合成1-溴代十二烷。确定优惠合成条件为:n(正十二醇):n(氢溴酸):n(浓硫酸)=1:1.25:1.15,回流时间3h。产品经气相色谱分析证明无副产物,收率92.5%,含量99.9%,产品经IR和折光率进行表征。

1-Bromododecane was synthesized from n-dodecyl alcohol using byproduct hydrobromic acid from 1- bromoadamantan process as raw material in the presence of the concentrated sulfuric acid. The optimal conditions were as follow： the molar ratio of n-dodecyl alcohol, hydiobromic acid and concentrated sulfuric acid was 1 ： 1.25 ： 1.15, the reaction time was 3 h. No by-product was detected in the product by GC. The yield of 1-bromododecane was 92.5% , and the purity was 99.9%. The product was characterized by IR and index of refraction.